The principal tributaries of the Plyussa within the district are the Lyuta, the Kureya, the Omuga, the Yanya, the Verduga, and the Paguba.

In the 12th century, the Antonov Monastery was founded and eventually grew to become a major landowner in the area.

Between 1851 and 1862, the railway connecting St. Petersburg and Warsaw via Pskov was built and crossed Luzhsky Uyezd.

The western part did not have direct transport connections with big cities and remained underdeveloped.

[11] On August 1, 1927, the uyezds were abolished, and Plyussky District was established, with the administrative center in the settlement of Plyussa.

On August 23, 1944, Plyussky District was transferred to newly established Pskov Oblast.

[3] The main agricultural specializations in the district are cattle breeding (with milk and meat production) and potato growing.

Additionally, the district specializes in eggs production and growing of crops, vegetables, and flax.

Margarita Yamshchikova, an author using an alias of Al. Altayev, owned an estate in the village of Lositsy.

[17] Nikolai Rimsky-Korsakov, a notable composer, owned two estates currently within the limits of the district, and lived there in 1894–1905 and from 1907 until his death in 1908.