Pocahontas is a village in Cape Girardeau County, Missouri, United States.

The Mound Builders went into decline in the 12th and 13th centuries, resulting in a depopulation of the area.

In the latter part of the 18th century, French and Spanish officials allowed the immigration of Shawnee and Delaware Indians from Ohio.

[7] Early American settlers to the area were the Abernathy and Little families, who farmed the land around present-day Pocahontas.

The Applecreek Presbyterian Church was established in 1821 and celebrates its 200 year anniversary in 2021,[8] German and Austrian immigrants began to settle around Pocahontas.

As of 2015, the town had four stores, several shops, a planing mill and a lumber yard.

[10] Pocahontas is located in north-central Cape Girardeau County, approximately thirteen miles north-northeast of Cape Girardeau and seven miles due west of Neelys Landing on the Mississippi River.

[11] According to the United States Census Bureau, the village has a total area of 0.10 square miles (0.26 km2), all land.

The racial makeup of the village was 99.12% White and 0.88% Black or African American.

Under Missouri Revised Statute 72-050,[16] towns with populations under 500 at the time of passage (1939) were declared to be villages.

Having been incorporated in 1893,[17] Pocahontas was unaffected by this statute, and is classified as a town despite its small population.