The school is located on the Eastern Shore of Maryland in the town of Pocomoke City in Worcester County.

The school building was renovated in 2010 which added new additions and has 122,500 square feet (11,380 m2) of space located on 22.02 acres (8.91 ha) of land.

[4] In January 2023, Principal, Jennifer Rayne was awarded the Human and Civil Rights Award at the Maryland State Education Association's Martin Luther King, Jr. Celebration and Racial Social Justice Summit in Baltimore, MD for her efforts with Speak Up, a club dedicated to elevating student voice.

The club explores the rich, diverse history and culture of all marginalized populations including women, immigrants, refugees, people of color, and members of the LGBTQIA community.

[7] Pocomoke High School has a very competitive sports history, and a deep root in winning championships, sometimes referred to as "Tradition" in the small hometown.