Poibrene (Bulgarian: Поибрене) is a village in the Panagyurishte municipality, western Bulgaria.

Due to the dam, the baths and the clear natural environment, many citizens of Panagyurishte have summer houses in or near the village.

Poibrene is located in the north-western part of the Pazardzhik Province on the left bank of the Topolnitsa river.

The land of the village encompasses 108 km2 in Sashtinska and Ihtimanska Sredna Gora separated by the Poibrene Gap.

During the Ottoman domination the village had a special status - the inhabitants did not pay taxes and were responsible for the security of the gorge.