Point MacKenzie is a census-designated place (CDP) in Matanuska-Susitna Borough, Alaska, United States.

In the book Shem Pete's Alaska, a collection of recollections about the lives of Upper Cook Inlet Dena'ina Athabascans, Point MacKenzie is identified as Dilhi Tunch’del’usht Beydegh, (“Point where we transport hooligan”), a trade site where the Dghelay Teht'ana ("The Mountain People") of the Talkeetna Mountains would trade with the Dena'ina of the Knik Arm.

It did not report again until 2000, when it returned as Point MacKenzie, and was made a census-designated place (CDP).

17.9% of all households were made up of individuals, and none had someone living alone who was 65 years of age or older.

There were 17.4% of families and 22.7% of the population living below the poverty line, including no under eighteens and none of those over 64.