In her comic book appearances, Poison Ivy is depicted as a doctor of botany-turned-misanthropic ecoterrorist in Gotham City named Pamela Lillian Isley, PhD (/ˈaɪzli/ EYEZ-lee) with the ability to control all plant life.

Empowered by an elemental force known as the "Green", Ivy attempts to protect the sanctity and supremacy of nature at all costs by lashing out against humanity, which brings her into conflict with Batman.

Diane Pershing, Tasia Valenza, Lake Bell, Tara Strong, and others have provided the character's voice ranging from animation to video games.

She is typically depicted barefoot with long flowing hair, plant vines extending over her limbs, and a green one-piece suit adorned with leaves, with occasional variations to her skin tone.

[14] Dr. Lillian Rose, PhD[15] is a promising botanist who is persuaded by Marc LeGrand into assisting him with the theft of an Egyptian artifact containing ancient herbs.

When her boyfriend has a car accident after mysteriously suffering from a massive fungal overgrowth, Isley drops out of school and leaves Seattle, eventually settling in Gotham City.

In subsequent issues, she states that she only started a life of crime to attain sufficient funds to find a location to be alone with her plants, undisturbed by humanity.

When Gotham City is destroyed in an earthquake and declared No Man's Land, she holds dominion over Robinson Park and turns it into a tropical paradise rather than fight over territory like most of Batman's enemies.

Batman battles Clayface and instructs Robin to blow up the lake bed above, allowing the rushing water to break apart the mud, effectively freeing Ivy.

[29] After arriving back from a year-long absence, Batman discovers that Ivy has been feeding people including "tiresome lovers", "incompetent henchmen", and those who "returned her smile" to a giant plant which would digest the victims slowly and painfully.

In an unprecedented event, her victims' souls merge with the plant, creating a botanical monster called Harvest, who seeks revenge upon Poison Ivy.

Shortly after, she escapes from Black Mask's control and forms an alliance with Catwoman and Harley Quinn, leading into the ongoing series Gotham City Sirens.

[32] She is eventually kidnapped and placed in a specialized containment unit by a researcher named Alisa Adams, but escapes and turns the table on her captor by binding her with vines.

Ivy then threatens Alisa into keeping her mouth shut about her true identity, telling her that she will change her mind and kill her if she reveals her secret to anyone.

Though she is specifically hand-picked by the team's leader, Black Canary, the other members of the group protest Ivy's inclusion, citing her violent past and connections to various murders.

[38] These suspicions are proven correct when Ivy poisons the team and forces them to attack corrupt companies she wants to destroy, until Katana apparently kills her.

Freeze, Pamela attacks the security guards sent to escort her out and is exposed to lethal doses of her chemicals, triggering a mutation that gives her green skin, immunity to all toxins, and the ability to manipulate plant life.

Under her human identity of Dr. Pamela Isley, she joins the plant sciences department at the famed Gotham Botanical Gardens, but things quickly get complicated when Luisa Cruz, Ivy's friend and mentor, is murdered via poisoning.

Ivy investigates the murder whilst completing a genetic engineering research project begun by Cruz that culminates in the creation of two plant-human hybrid children known as Rose and Hazel.

When the girls sneak out to see Gotham City at night for the first time, they cause an incident at a strip club that gets the police involved, and Ivy has to help them escape.

[49] In the "Ends of the Earth" arc of All-Star Batman, Poison Ivy goes into Death Valley where she conducts research on a barren tree to discover cures.

Upon examining it, Ivy realizes that the infected girl is already dead and Batman wanted to evoke her sympathy as he is actually seeking for a cure to combat the spread of the disease.

They escape when Poison Ivy violently reacts to her plants being harmed during an attack by several members of the Teen Titans and Suicide Squad, who all also have been twisted, as well as a Dark Robin.

[53] In the "Source Code" story arc of Batgirl and the Birds of Prey, Poison Ivy infiltrates and tries to take down Terracare, a company whose fertilizers contain a secret ingredient destructive to bee populations.

[54] After this arc, Poison Ivy is occasionally seen working at Terracare (now acquired by Gordon Clean Energy) or helping the Birds of Prey against villains (such as the Daughters of Gotham or the Calculator).

At the end, Swamp Thing (Alec Holland) reveals to Ethan Avery that the Green is trying to change Poison Ivy but hasn't succeeded.

Fueled by her guilt over the men she thought she killed in "The War of Jokes and Riddles", Poison Ivy uses her powers to take control of everyone on earth, except Batman and Catwoman.

Both innocently unaware of being a duplicate, the Ivy-double and Harley go on the run together when enemies attack, leaving behind the real Ivy feeling abandoned and betrayed.

She hatches a scheme to unleash some of her plant creations to cause havoc in Gotham, multiplying at contact with water, until Batman finally pays her a visit at the asylum.

In the thirteenth issue of the Poison Ivy Solo Series, Bruce refers to their past romantic relationship when talking to Pamela once she returns to Gotham.