Created by Fred Van Lente and Leonard Kirk, the character first appeared in Amazing Fantasy vol.

Upon attaining her doctorate, Rappaccini quickly became a world-renowned innovator of antitoxins and antidotes for various environmental poisons and nearly won a Nobel Prize.

[8] Recognizing the many environmental and political failings of Western civilization, Rappaccini decided that it was too corrupt to exist.

She joined a series of terrorist organizations, such as the pan-European leftist group the Black Orchestra, and then Advanced Idea Mechanics (A.I.M.

[10] Monica Rappaccini went underground for nearly two decades and studied potential power sources such as the sentient Uni-Power.

Following his numerous defeats, Rappaccini's splinter group absorbed more cells into a sizable rival faction.

attack on the United States Army Medical Research Institute for Infectious Diseases, it was thwarted by her estranged 19-year-old daughter, who had since joined forces with S.H.I.E.L.D.

[13] Following Ms. Marvel's thwarting of a plan to turn MODOK into a bomb, Rappaccini reunited the organization under her control.

She attempted to prevent MODOK from obtaining a weapon called the Hypernova and using it to erase all life on Earth.

[17] After a failed attempt to persuade Hank Pym to join A.I.M., she and her followers were stranded on Earth-Charnel when the Wasp deactivated her facility's dimensional screen.

's facility in Caspen, Colorado and fought the second Force, Monica sent her scheduler out to break up the fight and invite Iron Man to a luncheon.

While trying to get Stark to allow the merger to happen, Monica states that she did not sanction the revived Justine Hammer into attacking him and rigging his armors.

Monica orders Doctor Druid to do something scienceless to Iron Man as he is subjected to illusions of being called a failure by Howard Stark, Captain America, and Emma Frost.

Waker agents that granted them total immunity to all biological, chemical and radiological weapons, memetic antibodies, synthetic microbes that attack the human psyche and trigger pre-coded memories and impulses, hallucinogenic drugs that deliver programmed hallucinations before being absorbed into the system; and many innovative weapons of mass destruction, from gas attacks to nanobacterial bombs.

[18] Melody MacReady of Screen Rant called Monica Rappaccini one of the "most ruthless villains of the Marvel Universe," writing, "Monica is manipulative, prejudiced, murderous, and proud of what she does; this was best shown when she was one of the best villains in the game Marvel's Avengers.

[29] She worked alongside the Scorpion II and the Hulk to overthrow Governor Exodus' fascist mutant government in Australia when Scarlet Witch reality-warped Earth into a mutant-dominated society,.

When the Hulk became Australia's new leader, she secret plan to create a cybernetic army to overthrow Earth's mutant rulers was exposed.

When this warped reality was undone, the disoriented Rappaccini found herself stranded in Australia alongside Bruce Banner.

[30] Decades later her granddaughter Varina Goddard, a Senior Scientist in the future A.I.M., used the Uni-Alias as a power source for the Death's Head robot in her attempt to assassinate the United Nations Secretary General.