The Politecnica Salesiana University in Ecuador is an institution of higher education and Christian inspiration with Catholic character and a Salesian.

In 1887 the Ecuador government signed an agreement with Don Bosco for the Salesians to take under their responsibility the 'Catholic Protectorate of Arts and Trades' in Quito.

Ecuador was one of the first non-European countries to receive the children of the educator saint of Turin; the first was Argentina in 1877.

In April 2011, according to Ecuador's "Hoy" news, about 150 indigenous protestors prevented people from coming and going from and to the campus for several hours.

The Politecnica Salesiana University has four faculties and one postgraduate unit on campuses in Cuenca (C), Guayaquil (G), and Quito (Q).