The building was architectured by Louis Charlemagne a part of the Empire-style ensemble of Poltava city center, and constructed in 1828–1832.

Over the hundred-year activity period, various famous Ukrainian, Russian and Czech culture activists had worked at the institute.

In January, 1918, the Institute of Noble Maidens was evacuated to Vladikavkaz due to the October Revolution, where it started the process of founding and developing a municipal girls' school.

At the beginning of military action at the Eastern Front of World War II, the teachers and students had to evacuate the institute to Oral, Kazakhstan.

Thanks to the fruitful work of teachers and professors of the institution, the conditions were created for it to receive the highest accreditation of IV level, and be renamed to a technical university according to the Decree of the Cabinet of Ministers of Ukraine of August 29, 1994.