Polyozellin is a chemical which occurs in the mushroom Polyozellus multiplex.

It inhibits prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease.

Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.

[1] Structurally related dibenzofuranyl derivatives of polyozellin are known as kynapcins.

[2] This article about an aromatic compound is a stub.