Polyplacotomia is a class of placozoans, to this date only comprising Polyplacotoma mediterranea.

[1] Their morphology is strikingly different from other placozoans in Uniplacotomia, exhibiting a highly ramified, branching structure with multiple amoeboid projections.

It differs from Uniplacotomia by 76 uniquely present and 600 absent genes.

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