PUP San Pedro Campus was established on April 9, 2002, as an open university center by virtue of a memorandum of agreement signed by then-Mayor Felicismo A. Vierneza of San Pedro, Laguna and then PUP President Ofelia M. Carague.

PUP San Pedro initially offered a single curricular program, Bachelor of Science in Entrepreneurial Management.

Two sections totaling 119 students enrolled in the courses were housed in a borrowed two-room building at the San Pedro Manpower Training Center (SPMTC) at the Elvinda Subdivision.

The San Pedro, Laguna campus of PUP has an Eco Park and Butterfly Sanctuary.

The students are divided according to their respective organization to win an individual categorized competition.