While primarily a virtual university, it has a physical campus that houses admin and faculty offices in Los Baños, Laguna, with Mega Learning Hubs (MLH) in Manila and Cebu.

UPOU offers accredited graduate and undergraduate degrees as well as diploma courses and Professional Teaching Certificates (PTC) to Filipino and international students in more than 70 countries.

[5] It also offers MOOCs on various subjects through its official platform, Massive Open Distance eLearning (MODeL), and hosts its degree programs through its official student portal, MyPortal, both learning platforms were developed using a free and open-source learning management system called Moodle.

In January, 2024, UPOU is offering free 24 Massive open online courses which cover various categories, including "ODeL teacher accreditation, child rights protection, technology for teaching and learning, educational media production, sustainable development, business analytics, introduction to distance education, and more.

These centers are the venues where students can conduct and seek advice on transactions, activities and procedures regarding application for admission, registration, student orientation, distribution of course materials, dropping of subjects, filing leave of absence, examinations, accessing library materials, face-to-face tutorials (if available) and tutorials on basic computer and internet literacy.

Open University Headquarters is located in Los Baños, Laguna, close to the International Rice Research Institute.

This gives the effect of the flag lifting the Oblation into greater heights and gives it the boundless reach that is symbolic of UPOU's prime objective of widening access to UP quality education.

The university also maintains a satellite office at the National Computer Center Building in Diliman, Quezon City.