She debuted as child artist with the Malayalam film Onnu Muthal Poojaym Vare in 1986.

[2] She made a comeback in 2019 film Virus which was critically acclaimed and a box office success.

[3] Poornima Indrajith was born to Mohan and Shanthi, in a Tamil family that settled in Kerala.

Poornima started her career as a model and then acted in a Successful Tamil TV serial Kolangal.

[10][11] After 17 years, she made a comeback with Virus which was included in The Hindu's top 25 Malayalam films of the decade.