[8] Pope John XXIII Regional High School has a Catholic philosophy in accordance with Church teaching.

The uniform policy is often strictly enforced to ensure students live up the proper standard expected of them by the administration and faculty.

[16] The 1964 baseball team won the Non-Public C state championship, defeating Saint James High School in the tournament final.

[17] Since the playoff era started in 1974, the school's football team won 18 state championships under coach Victor Paternostro.

[19][20] The 1979 team had a 10-0-1 record after winning the Parochial B North final over Immaculate Conception High School of Montclair by a 28-0 score.

[21] A 28-0 win against St. Cecilia High School in the 1981 Parochial B North championship game gave the team a 10-1 record for the season.

[22] A 27-0 championship game win against Immaculate Conception of Montclair gave the team the 1982 Parochial A North state sectional title.

[24] The 1986 team took the Parochial B North title and finished the season at 10-1 after a 35-0 win against Phillipsburg Catholic High School in the championship game.

[27][28] The 1993 team won the inaugural Parochial Group II title with a 14-0 win in the championship game against Marist to finish the season with a 10-1 record.

[29] The 2001 team used a strong defense to finish the season with a 9-1 record after winning the Parochial Group II state title by defeating Paterson Catholic High School by a score of 13-12 in the finals.

[30] In 2002, the football team won the Non-Public II state sectional championship with a 41-12 win against Queen of Peace High School in the tournament final.

[34] The boys tennis team won the Non-Public Group B&C state championship in 1982, against runner-up Saint Mary's High School (South Amboy) in the final match of the tournament.

[36] The 1990 team won the program's seventh straight Parochial B title, defeating Mater Dei High School by 45-32 in the finals.

[38] The 1990 team won the program's first championship, defeating DePaul Catholic High School by 51-32 in the Parochial B finals.

[47] The boys basketball team won the Non-Public Group A state championship in 2015, defeating Christian Brothers Academy in the final of the tournament.

[51] The finals were held on board the International Space Station on small SPHERES robots which maneuver in zero gravity.

Although the tournament only officially named the top three winning teams, Pope John's scores during elimination rounds placed them at fourth position nationally.