Pope Paul VI College is a band 1B Roman Catholic girls' secondary school in Hong Kong.

The school was founded by Missionary Sisters of the Immaculate in 1969.

In 1967, Lorenzo Bianchi, then-Roman Catholic bishop of Hong Kong, invited the Missionary Sisters of the Immaculate (PIME Sisters) to establish a girls' secondary school in the Tsuen Wan area, which the Hong Kong government was developing into a new town.

[1] Construction of the school building, beside the Shek Lei Resettlement Estate, began in July 1969.

Classes began in September 1969 at the Shek Lei Catholic Primary School.