Port Fulton was a town located two miles up the river from Louisville, within present-day Jeffersonville, Indiana.

[2] In April 1853 the city of Jeffersonville attempted to annex Port Fulton, only to be stymied by its residents.

[3] The third-largest Civil War hospital, Jefferson General Hospital, was operated there, formed from the Brighton estate owned by Jesse Bright that was confiscated by Union authorities.

However, Port Fulton's population declined to 971 in the 1920 census.

This allowed Jeffersonville to finally annex Port Fulton in 1926.