It is named after the community of Port Hood immediately to the east on Cape Breton Island.
It housed a booming lobster cannery, however, during a winter storm in the late 19th century, the thin sand spit connecting Port Hood Island was washed away.
Rocks that made up the road still remain and now form what residents call the "Breakwater".
The island was originally settled by Protestant Loyalists, giving contrast to the Catholic majority in the Port Hood area.
The island church enjoyed the services of the Port Hood minister who also served Mabou.