Port LaBelle is a census-designated place (CDP) in Hendry and Glades counties, Florida, United States.

[5] It is part of the Clewiston, Florida Micropolitan Statistical Area (μSA).

Florida State Road 80 runs through the northern part of the community, leading east 30 miles (48 km) to Clewiston and west through LaBelle 32 miles (51 km) to Fort Myers.

According to the United States Census Bureau, the CDP has a total area of 8.2 square miles (21.2 km2), all land.

15.0% of all households were made up of individuals, and 6.5% had someone living alone who was 65 years of age or older.