Porta Romana is one of the portals in the medieval Walls of Siena.
The gate exits near the Basilica of San Clemente and leads south out of town to Via Enea Silvio Piccolomini.
In 1417, Taddeo di Bartolo was commissioned to paint the Madonna icon on the inner portal, dedicated to the protection of the city.
The painting was further retouched by Sassetta and later Sano di Pietro who completed it in 1466.
Due to the state of decay, the remaining fresco was transferred in 1978 to the Basilica of San Francesco, Siena.