Portimine A is a cyclic imine natural product produced by the dinoflagellate microalgae Vulcanodinium rugosum.

It is a drug lead due to its anti-cancer activity.

[1] It seemingly inhibits ribosomal translation activity through an interaction with NMD3[1], leading to activation of the inflammasome.

[2] It was the causal toxin behind an severe inflammatory skin disease in Senegalese fishermen in 2020 and 2021.

[2]