Porto Empedocle (Sicilian: 'a Marina) is a town and comune in Italy on the coast of the Strait of Sicily, administratively part of the province of Agrigento.

The primary industries of Porto Empedocle are agriculture, fishing, ironworking, pharmaceuticals and rock salt refining.

Porto Empedocle is the second comune with the lowest amount of degree days in Italy.

From 1549 to 1554, by order of the viceroy Vega, Torre del caricatore of Girgenti, already known during the ancient times (as it probably already existed before the Angevin period), was restored.

It had been built to protect against the Saracen pirates, together with the whole system of the Coastal towers of Sicily.