San Biagio Platani borders the following municipalities: Alessandria della Rocca, Casteltermini, Sant'Angelo Muxaro, Santo Stefano Quisquina.

Gaetano Di Giovanni, in his work "Notizie storiche su Casteltermini e il suo territorio", attributes the foundation of the urban settlement to Mariano Gianguercio in 1648.

This settlement now consists of several key features of the main street of San Biagio Platani, still known by its prior official name " Via Piazza, or "La Chiazza" in Sicilian.

After the suppression of feudalism in Sicily, the village like most of the area began to be characterized by a huge shift towards the Americas and the general marginalization of the island.

At the time, a village with more than 80 people gave the prince the right to a seat in parliament or to one more vote, in addition to power over his subjects through the faculty of administering justice within his own fiefdom.

The central point of the street, located near the Mother Church, represents the center of gravity of the town, from which the other main axis starts, which is today's Viale della Vittoria, formerly Strada Chiarenza.

The decline of the Sicilian noble families did not spare even the lord of San Biagio, who moved to the Villa della Noce in Palermo, with a series of contracts drawn up at the end of the eighteenth century and handed over all possessions to the gabelle.