It follows the story of Carlo Santillan, played by Martin Escudero, a call center agent who, after having previously lived a hedonistic lifestyle, later discovers that he has since developed HIV/AIDS, and attempts to track down who might have infected him.

Positive follows the story of Carlo Santillan (Martin Escudero), who since grade school without knowing lived a very hedonistic lifestyle.

Describing himself as the "life of the party", he freely consumed drugs and alcohol, and had numerous sexual partners since he was 12 years old.

After entering rehab at the urging of his mother, Esther, Carlo has attempted to set his life straight: he has found work as a call center agent, rising through the ranks until he became operations manager, and has since married his wife, Janis (Helga Krapf), who he met when high school, and who is three months pregnant with their child.

Despite setting his life straight, Carlo started developing recurrent pneumonia symptoms, and at the urging of his doctor, had his blood screened for possible HIV infection.