Homme has stated that preparing Post Pop Depression was one thing that helped him cope with the aftermath of the November 2015 terrorist attacks involving his other band, Eagles of Death Metal.

[4][6] The lead single from the album, "Gardenia", was debuted on The Late Show with Stephen Colbert on January 21, 2016.

[16] Clash magazine critic Josh Gray was positive in his review, writing that the record "is what it says on the tin and Iggy Pop is what every aspect the music revolves around".

[25] Matt Wilkinson of NME praised the album and gave it a perfect score, describing it as "an intelligent, sassy garage rock record that's obsessed with sex and death" and "a solid gold proof of his [Pop's] genius".

[2] Pitchfork's Stuart Berman stated that "if Post Pop Depression's refined execution has you missing the more unhinged Iggy of old, rest assured, he's not going down without a fight".

[22] Andy Gill of The Independent wrote that "it's as if he's [Pop's] grown so sick and tired of the veneers of respectability cocooning American sensibilities that, reverting to type once more, he wants to be your dog again".