Over its five seasons, The Ren & Stimpy Show featured a varied cast of characters, some who appeared in as few as one episode, and some who were practically regulars.
Ren Hoëk (voiced by John Kricfalusi in Seasons 1–2 and Adult Party Cartoon, Billy West in Seasons 3–5 and most laughter and screaming, and Chris Edgerly in Nicktoons MLB) is a scrawny "Asthma-Hound" Chihuahua with a fairly long, rat-like, pink tail (which constantly disappears due to the character's animation limits), pink eyes and tan fur.
Martin "Dr. Toon" Goodman of Animation World Magazine described Ren as "scrawny", "dyspeptic", and "violently psychotic".
Kricfalusi originally voiced Ren in a manner that he describes as "a bad imitation of Peter Lorre".
His significant physical features a large blue nose, purple eyelids, no tail, white gloves with fingernails on them, human-style buttocks, flat feet and a brain the size of a peanut (despite some intelligence, such as when cooking and inventing).
He also has a strong attachment to his "first material possession" which is a litter box (given to him in the pilot episode) and even though Ren destroys it (by bashing it on his head in "Fire Dogs" or dumping it in acid in "Ren's Bitter Half"), Stimpy always reacts strongly to it by crying, panicking or fainting, though it always appears again in some later episode.
[1] While the duo's relationship has been ambiguous in the original series, Stimpy is occasionally depicted in a feminine role, helping with housework and maintaining the residence (if any) while Ren goes to work.
Stimpy likes to create destructive electronic devices, whenever he has sufficient intelligence for it in episodes and feels a fixation for "sensory pleasures of fresh kitty litter".
Horse partakes in a wide range of roles to comedic effect due to his nature as a cameo based character Mr.
Powdered Toast Man (voiced by Gary Owens[2] in most appearances, Darrin J. Sargent in the first "Powdered Toast Man" commercial, Corey Burton in Nicktoons MLB, David Kaye in Nickelodeon All-Star Brawl and Nickelodeon Kart Racers 3: Slime Speedway, Michael Berger in Smite) is a melodramatic superhero and a spokesperson for Powdered Toast, a breakfast treat that "tastes just like sawdust".
He is depicted as extremely incompetent in heroics, causing unintentional destruction and lax treatment of the people he saves.
Powdered Toast Man has a number of abilities and, like many superheroes, has a mysterious background and an alter ego.
Powdered Toast Man can fly by flatulence, by inserting his head into a special toaster and launching from it, or by pushing off from the ground.
His powers include projection of offensive weapons: high-velocity raisins shot from his mouth, hyper-corrosive croutons fired from his armpit, butter pats launched from the top of his head, and acidic marmalade from his navel.
Muddy Mudskipper (voiced by Harris Peet) is a mudskipper (a species of fish capable of crawling out of water and breathing air through its skin) with the voice and personality of a grizzled vaudeville comedian who hosts his titular children's television series, which is depicted as a low-effort production with subpar animation and persistent product placement.
[3] Besides being a huge television star, Muddy has dabbled in villainy, at one point kidnapping the Pope (voiced by Frank Zappa) before being foiled by Powdered Toast Man.
The show's theme song (written by John Kricfalusi, Bob Camp & Charlie Brissette) plays up Muddy's particular physical traits.
Pipe is depicted as a standard housewife with seemingly no unique traits, though it is revealed that she had copious amounts of body hair in "Rubber Nipple Salesmen".
The couple have two children named Eugene and Shawn, who are literate and act like gangsters, frequently leaving the residence without notifying their parents.
John Kricfalusi originally wanted his name to be Raymond Spum (a reference to the pseudonym that he used in episodes he considered unsatisfactory), but after his termination from the series Nickelodeon renamed him Wilbur Cobb after the story editor.
He was voiced by Harris Peet in the entire original series and at the beginning of the character's appearance in the Adult Party Cartoon.
Mrs. Buttloaves is a morbidly obese and homely old woman dressed in a bulging pink night gown and hair curlers.
He is depicted as a highly aggressive individual, having extremely warped beliefs to the point he believes Republicans are communists.