Powdersville High School (PVHS) is a public high school in Powdersville, South Carolina, United States, a suburb of Greenville located in Anderson County.

[2] Prior to the opening of PVHS, students who lived in the Powdersville area attended Wren High School.

However, due to growth in the area, Anderson School District 1 voted in 2008 to build a high school for Powdersville.

The school started with 265 students in grades 9–10.

In 2015–2016 school year, it enrolled around 840 students.