Prairie Pothole is a year-long depressional freshwater wetland lake found in Stutsman County, North Dakota.

The watershed is managed as part of the Chase Lake National Wildlife Refuge.

[1] It is filled by precipitation in the form of rain and snowmelt during spring and summer.

[2] The geology of the lake is glacial mud, clay, and silt.

Biological surveying is performed through electrofishing and sampling for zooplankton and macroinvertebrates.