In the same season the team ran in the 500 cc class with Japanese rider Norifumi Abe aboard a Yamaha YZR500.

The team switched to Ducati motorcycles in 2004 using the previous season's Desmosedici GP3 and signing 2003 Superbike World Champion Neil Hodgson and runner-up Rubén Xaus, Ducati's factory riders for the 2003 World Superbike Championship season.

The team ran into financial difficulties mid-season and was not able to run a test program; their best result was a third place for Xaus in Qatar.

[9][10] A podium in Brazil was the team's best result, while Biaggi scored two wins and finished the championship in third place.

Pramac ended its relationship with Pons Racing to start a new project with Ducati and d'Antin.

Hofmann had a more average season and he injured his hand in practice at Mazda Raceway Laguna Seca.

Luis d'Antin resigned from the team midway though the 2008 season, at the German Grand Prix at the Sachsenring.

[17] On 19 August 2009 it was announced Aleix Espargaró would race for Pramac in Indianapolis and Misano, the seat having been filled by Michel Fabrizio at Brno.

He temporarily replaced Kallio who in turn filled in for Casey Stoner at the Ducati works team.

The Pramac team competed in the 2011 championship with riders Loris Capirossi and Randy de Puniet[19] and achieving a sixth place as a best race result.

Damian Cudlin and Sylvain Guintoli entered some races replacing an injured Capirossi.

[20] For 2013, Pramac Racing received the factory supported team Ducati status and fielded two factory-specification Desmosedici for works riders Andrea Iannone and Ben Spies.

[25][26] Martín left Pramac for Aprilia[27] while Franco Morbidelli joined VR46 Racing Team[28] after the season.

For 2025, Jack Miller and Miguel Oliveira will ride factory-spec Yamaha bikes[29] as Pramac Racing moved on from Ducati.