In 2003 Prechae Rodriguez' skills nearly earned him national recognition when he participated in the open run of the AND-1 Mix Tape Tour at the University of South Florida (USF) SunDome in Tampa, Florida where Rodriguez instantly became a fan favorite of the more than 500 fans.

He was named Second-Team All-Kansas Jayhawk Community College Conference, J.C Grid Wire honorable mention, SuperPrep Junco 100, and CollegeFootballNews.com's Top JUCO Wide Receivers.

As a member of the Auburn Tigers football team, he saw action in 11 games, catching 13 passes for 240 yards and one touchdown.

During the 2006 Iron Bowl Game against Alabama, he caught a 22-yard touchdown pass from quarterback Brandon Cox in the third quarter that served as the game-winner for the Auburn Tigers.

[7] On May 7, 2008, he signed with the Hamilton Tiger-Cats of the Canadian Football League and was expected to play a big role.

Against the Edmonton Eskimos on July 26, Richie Williams threw a pass to Rodriguez for 46 yards which helped Jesse Lumsden score a touchdown on the next play.

[9] On September 13, once again against the Eskimos, Rodriguez caught two touchdown passes from quarterback Casey Printers including an 18-yard catch that ended a 97-yard possession.

[11] In a late season game against the first place Montreal Alouettes, Rodriguez recorded 12 catches for a total of 198 yards with three touchdowns.

Although Dressler ended up winning, Rodriguez received the finest players CFL 2008 East Division Rookie of the Year Award, Frank M. Gibson Trophy.

On February 24, 2010, Rodriguez was traded to the Saskatchewan Roughriders for non-import Canadian Adam Nicolson, a third round selection in the 2011 CFL Draft, and the rights to a negotiation list player.

[21] On August 15, 2011, Rodriguez was signed by the Edmonton Eskimos after slotback Fred Stamps went down with an abdominal injury.

[30] In his performance against Tampa Bay in Week 12, Rodriguez had his best game of the season, helping beat his former team for 157 yards and 5 touchdowns, and he also tied a career-high with 12 receptions in the contest.

[31] On February 6, 2014, Rodriguez was traded to the Pittsburgh Power in exchange for Markell Carter and Ben Ossai.

[32] Rodriguez missed 8 games due to a high ankle sprain but nonetheless finished the regular season with 85 receptions for 1,138 yards and 32 touchdowns.

[34] On February 21, 2024, Rodriguez was arrested and charged with one count of child abuse after he was accused of punching a non-verbal student at the Eisenhower Exceptional Center in Gibsonton, Florida.