Prek Prasab Wildlife Sanctuary (Khmer: ដែនជម្រកសត្វព្រៃ​ព្រែក​ប្រសព្វ) is a 12,770 ha protected area in eastern Cambodia, located in Kratié province.

The area was formally protected in October 2018.

[1] The area is of particular importance for the endangered hog deer, (Axis porcinus), with an estimated population 84 individuals.

[2][3] Hog deer were thought extinct in Cambodia until the 2006 rediscovery of a population in this area.

[4] The protected area is under threat from illegal forest clearance, snaring, and poaching with dogs.