The tenure of Ismail Sabri Yaakob as the prime minister of Malaysia began on 21 August 2021 when he was appointed to the office by Yang di-Pertuan Agong Al-Sultan Abdullah Ri'ayatuddin Al-Mustafa Billah Shah, following the resignation of his predecessor, Muhyiddin Yassin, after a political crisis.

[4][5] A few days later, Ismail Sabri was chosen as the prime ministerial candidate by Barisan Nasional (BN) coalition and was also endorsed by other coalition parties namely Perikatan Nasional (PN), Gabungan Parti Sarawak (GPS), and Gabungan Rakyat Sabah (GRS) as well as several independent MPs of the Dewan Rakyat.

[23] On 25 August 2021, the Prime Minister-elect, Ismail, will meet with the Yang di-Pertuan Agong to submit his list of cabinet nominees.

On 10 September 2021, he claimed that the Cabinet was committed to undertake several parliament reforms and transformations, including tabling anti-party hopping law.

The Keluarga Malaysia (in English: Malaysian family) is an idea introduced by the Ismail Sabri on 22 August 2021 in his inaugural speech as prime minister.

This concept, among others, calls on Malaysians to set aside differences in rehabilitating the country to mobilize energy in the challenge of facing the COVID-19 pandemic and realizing the Shared Prosperity Vision 2030.