Prescott High School is a public high school located in the city of Prescott, Wisconsin.

The Cardinals have been members of the Middle Border Conference since 2002; previously they were members of the Dunn-St. Croix Conference.

They have won state titles in baseball (1994 and 2012), and in dance (2000-2013 and 2015).

Prescott's main rival throughout the years has been and continues to be Ellsworth High School.

This Wisconsin school-related article is a stub.