Preston Xavier Burke,[2] M.D., F.A.C.S., is a fictional character from the medical drama television series Grey's Anatomy, which airs on ABC in the United States.

Burke is introduced as an attending cardiothoracic surgeon at the fictional Seattle Grace Hospital, and his romantic relationship with intern Cristina Yang (Sandra Oh) becomes one of the central storylines of the show during its first three seasons.

He completed his pre-medical studies at Tulane University, where he pledged Kappa Alpha Psi, and graduated first in his class from Johns Hopkins School of Medicine.

During his time in college, he met Erica Hahn (Brooke Smith), his rival who graduated just behind him, starting a long-standing competitive relationship.

Although they initially broke off their romance due to fears of damaging their professional reputations, they rekindled their relationship after Cristina suffered a miscarriage.

The two began living together, and Burke's structured, meticulous lifestyle clashed with Cristina's more chaotic approach, though they managed to make it work.

The character of Preston Burke was originally envisioned as a Caucasian man, with actor Paul Adelstein, who later starred in Grey's Anatomy's spin-off Private Practice, slated for the role.

[5][6] Isaiah Washington, who was initially considered for the role of Derek Shepherd (which went to Patrick Dempsey),[5] was then called back by Shonda Rhimes to portray Burke.

At the start of the series, Burke is one of the three African American characters, along with Miranda Bailey (Chandra Wilson) and Richard Webber (James Pickens, Jr.).

In October 2006, reports emerged that he had used a homophobic slur during an argument with co-star Dempsey, directed at T. R. Knight (who portrayed Dr. George O'Malley).

[13] He also claimed that racism within the media played a role in his firing, which he discussed in interviews, including an appearance on CNN's talk show Larry King Live, where he presented his side of the controversy.

In March 2014, Rhimes announced that Washington would return to Grey's Anatomy for a special episode in Season 10 to help conclude Cristina's storyline.

Washington also highlighted Burke's "determination" and "commitment" as key traits of the character, showing his professionalism and dedication to both his career and his personal relationships.

Rhimes referred to the relationship between Burke and Yang using the portmanteau "Burktina," noting that the episode "Losing My Religion" was one of her favorites featuring the couple.

It was regarded as "one of the most interesting relationships on the show", with The Orange County Register calling it "one of the most touching and funny attractions of Grey's Anatomy.