The station is managed by ScotRail and is on the Ayrshire Coast Line.

Prestwick Town is one of the few stations on the Ayrshire Coast Line that remains staffed (the ticket office being staffed part-time, seven days per week - Monday - Saturday 06:35 - 17:50, Sunday 09:10 - 16:50).

Facilities include a medium-sized car park and a café is present in the station building itself.

The station has a basic service to Glasgow Central and Ayr of four trains per hour Mon-Sat (with a few weekday peak extras).

Of these, two serve all stations to Paisley Gilmour Street en route, whilst the others run fast north of Kilwinning.