Priapulus tuberculatospinosus is a species of priapulid worm within the family Priapulidae.

[1] The species is found distributed in the southern hemisphere around Antarctica in the Southern Ocean and south Atlantic Ocean, with it living at depths of 6 to 5289 meters in benthic environments.

[2][3][4] In this distribution, P. tuberculatospinosus is preyed upon by animals such as gummy sharks and Patagonian blennies.

[4]