Born in Bologna, he trained under Giulio Romano in Mantua and became a pupil of Innocenzo da Imola, executing decorations at the Palazzo Te before securing a position in the court of Francis I of France in 1532.
Following Rosso's death in 1540, Primaticcio took control of the artistic direction at Fontainebleau, furnishing the painters and stuccators of his team, such as Nicolò dell'Abate, with designs.
He made cartoons for tapestry-weavers and, like all 16th-century court artists, was called upon to design elaborate ephemeral decorations for masques and fêtes, which survive only in preparatory drawings and, sometimes, engravings.
Primaticcio's crowded Mannerist compositions and his long-legged canon of beauty influenced French art for the rest of the century.
Primaticcio turned to architecture towards the end of his life, his greatest work being the Valois Chapel at the Abbey of Saint-Denis, although this was not completed until after his death and was destroyed in 1719.