[3] His earliest documentation finds him at Venice after 1533, with his wife and infant son, living under the protection of his Aretine compatriot (and possible kinsman), Pietro Aretino, who introduced him to the circle of Titian.
[4] Taking advantage of his rival Benvenuto Cellini's being in prison at the time, he secured the role of designer for the Papal mint in Ferrara (1538–40) but was forced to withdraw under accusations of counterfeiting levelled by Pellegrino di Leuti, the jeweller of the Farnese Pope Paul III.
Here he entertained Giorgio Vasari, who noted Leoni's large collection of plaster casts after the Antique, dominated by a stucco of the equestrian Marcus Aurelius from the Campidoglio in his courtyard.
He lived in Milan thereafter, despite calls from his patrons to base himself, or at least present himself, at court, claiming that only there could he obtain the proper materials for his work – a notable contrast with Giambologna who was never allowed to leave Florence by his Grand Duke, as he bitterly complained, for fear the Habsburgs would ensnare him.
For the cathedral of Milan, Leone executed the five bronze figures for the monument of the condottiero Gian Giacomo Medici, brother of Pope Pius IV, in a marble architectural setting that Vasari attributed to a drawing by Michelangelo.
He pioneered what became a common Baroque format for a portrait bust; mounted on a pedestal, and truncated at mid-chest, or the bottom of the stomach (often defined by an armoured breast-plate), sweeping up at the sides to just below the shoulders.