The prime minister of Antigua and Barbuda is appointed by the Governor-General under the terms of the Constitution.

If there is no party that has an undisputed leader, or no party that maintains the support of the majority of the House of Representatives, the Governor-General may appoint a member that is most likely to maintain the support of the majority of the members, and who is willing to hold the role of prime minister.

[3] The Governor-General may authorize another member of the Cabinet to perform those functions (other than the functions conferred by section 74(2) of the constitution) when the Prime Minister is not present in Antigua and Barbuda or is unable to do so due to illness or because of the restrictions of section 73(4) of this Constitution.

[2][3] The prime minister advises the Governor-General on appointments to the Cabinet of Antigua and Barbuda.

[2][3] Under section 73 of the constitution, the Governor-General must dismiss the Prime Minister or dissolve parliament in the event of a successful vote of no confidence.