[1][2] The specific name refers to Lake Mistassini in Quebec, Canada.

[2] It is native to the northeastern United States and much of Canada.

[3] Although it is the most widespread species of North American primroses,[4] P. mistassinica is considered rare or imperiled in many parts of its range.

[3] Its rarity is often related to its restrictive habit requirements, particularly toward the southern extent of its range.

[5] Habitats for this plant include damp cliffs, marshes, bogs, and the shores of lakes and rivers.