The Prince Louis Rwagasore Clinical Hospital (French: Hôpital Clinique Prince Louis Rwagasore, CPLR) is a hospital in Bujumbura, Bujumbura Mairie Province, Burundi.

The Hôpital Prince Régent Charles, completed in 1949, provided treatment to citizens refused by the Doctor Rhodain hospital.

For a fee, a doctor, nurse and other medical workers treated patients suffering from chronic illnesses in their own homes.

[5] The hospital is a large yellow-painted building, now named for Louis Rwagasore, a hero of the independence struggle.

A 2022 report described the hospital, which once welcomed VIPs, as having gradually deteriorated due to chronic underfunding.