On 23 October 1821 Prince Regent, Joseph White, master, sailed from Falmouth for the Leeward Islands.

On 23 June 1824, Prince Regent, under the command of Lieutenant William Lugg (RN; acting), sailed for Brazil, via Madeira.

On 22 April 1825, Prince Regent, under the command of Lieutenant William Lugg (RN; acting), sailed for Jamaica and Cartagena, Colombia.

On 22 August 1825 Prince Regent, White, master, sailed from Falmouth to Buenos Aires and Montevideo.

On 10 February 1826 Prince Regent, Donellan (acting), master, sailed for New York, via Halifax on both the outward and inward bound legs.

The Admiralty as a matter of policy did not want two different vessels on active duty to share a name so it renamed her because in 1823 the Royal Navy had commissioned the 100-gun First rate HMS Prince Regent.

She had sighted Barbados late in the afternoon of 5 June and Lieutenant White decided to lie-to for the night.

It proved impossible to get her off during the night and by daybreak it was clear that she was on a reef about two miles off the southern point of the island.

She landed her mails but despite attempts by local boats to lighten her, she could not be got off and by mid-afternoon she was flooded, ending all hope of rescuing her.