Prince Sigismund of Prussia (German: Franz Friedrich Sigismund; 15 September 1864 – 18 June 1866) was the fourth child and third son of the Crown Prince and Crown Princess of Prussia, later German Emperor Frederick III and Empress Victoria.

He was a grandson of William I of Prussia and Victoria, Queen of the United Kingdom.

Prince Sigismund was born at the New Palace in Potsdam, Germany, in 1864 and known as "Sigi" to his family.

He died from meningitis at the New Palace on 18 June 1866, aged twenty-one months.

His mother's grief and despair were intense as his father, leading the Prussian army into battle against Austria, had taken all available doctors thus making it impossible for her to alleviate the suffering of her child or prevent his death.