Prince of Wales Collegiate is a public high school located in St. John's, Newfoundland and Labrador, Canada.

Prince of Wales offers a number of Advanced Placement courses and concurrent studies affiliated with Memorial University.

They offer local courses in French Immersion, Spanish, Russian and Italian that come with the opportunity for international travel, and strong programs in arts, theatre and music.

1886 a major expansion and reconstruction program to the building, adding a Model school (teacher training) and a students’ residence (the College Home).

Circa 1957, again due to a lack of space, Prince of Wales Annex on LeMarchant Road opened for Grade six.