After an appeal for funds in 1870, the Catherine Hayes Hospital—a separate facility located in Avoca Street, Randwick—opened, reputedly with plans approved by Florence Nightingale.

In 1919 the 1918 flu pandemic reached Sydney, requiring the full resources of the hospital.

In 1934 the Coast Hospital was renamed the Prince Henry Hospital of Sydney on the occasion of the visit of the Prince Henry, Duke of Gloucester, and major building works commenced to increase the capacity to 1000 beds.

In the early 1900s, Sir James Joynton Smith, a hotel, tourism and sports entrepreneur, began a push for a public hospital in South Sydney.

The Eastern Suburbs Hospital opened in February 1935 on a 20,000-square-metre (5-acre) site near Queen's Park, after agitation from the community from 1924.

The Eastern Suburbs hospital officially closed on 30 June 1980; the buildings now form part of Moriah College.