[1] She was the daughter of Frederick I, Duke of Saxe-Gotha-Altenburg (1646–1691) and Magdalena Sibylle, Duchess of Saxe-Weissenfels (1648–1680).

Her father was a fourth-generation descendant of John Frederick, Elector of Saxony in direct male line.

He married Dorothea Susanne of Simmern, a daughter of Frederick III, Elector Palatine.

John and Dorothea Maria were parents to Ernst I, Duke of Saxe Coburg.

They had the following children: Via her eponymous daughter, Anna Sophie was an ancestor of both Queen Victoria and Prince Albert and their cousins Carlota of Mexico and Leopold II of Belgium