The Princess Caroline-Mathilde Alps (Danish: Prinsesse Caroline Mathilde Alper) are a mountain range system in the Holm Land Peninsula, King Frederick VIII Land, northeastern Greenland.

[2] The Princess Caroline-Mathilde Alps run from north to south across the western half of the Holm Land peninsula.

The Princess Elizabeth Alps located to the north across the Ingolf Fjord display a similar structure.

The range is bound to the north and northwest by the inner Ingolf Fjord, to the east by the flatter eastern part of Holm Land, to the west by the Vandre Valley (Vandredalen) and the Saefaxi River (Sæfaxi Elv), and to the south by the Marmorvigen and the inner Hekla Sound, the NW branch of the Dijmphna Sound.

The nearest settlement is Nord, a military outpost with an airfield located about 120 km to the north.