Princess Charlotte Sophie of Saxe-Coburg-Saalfeld, Duchess in Saxony (24 September 1731 – 2 August 1810) was a German duchess.

She was the daughter of Franz Josias, Duke of Saxe-Coburg-Saalfeld and Princess Anna Sophie of Schwarzburg-Rudolstadt.

Charlotte Sophie married Duke Louis of Mecklenburg-Schwerin (6 August 1725 – 12 September 1778), younger son of Christian Ludwig II, Duke of Mecklenburg-Schwerin.

They had two children: This article about a German duchess is a stub.

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