She made nine voyages to Madras and Bengal for the British East India Company (EIC) before she was broken up in 1831.

Princess Charlotte of Wales, under the command of Captain John Craig, left Falmouth on 15 May 1812, bound for Ceylon and Bengal.

[3] Captain Charles Besly Gribble sailed Princess Charlotte of Wales on her third trip, leaving The Downs on 14 March 1817, and reaching Madras on 9 July and the Hugli river 9 August.

On the return trip Princess Charlotte of Wales reached Madras on 4 January 1820, Colombo on 1 February, and St Helena on 29 March.

[3] Captain Charles Besly Gribble again commanded Princess Charlotte of Wales, leaving Plymouth on 28 May 1823.

[3] Captain Christopher Biden sailed from Plymouth on 25 April 1825 and left Trincomalee on 10 August.

The return trip left Saugor on 22 December, reached St Helena on 1 April 1826, and Ascension ten days later.

The return trip left Saugor on 30 December, reaching Madras on 11 February 1828, and St Helena on 14 April.

[3] Princess Charlotte of Wales left the Downs on 8 June 1829 under the command of Captain Christopher Biden.