Elisabeth and Adolf Friedrich had four children: Following the death of her father-in-law on the 30 May 1904, she became The Grand Duchess of Mecklenburg-Strelitz following her husband's ascension to the throne.

After her husband's death in 1914, she was titled Grand Duchess Elisabeth of Mecklenburg-Strelitz, since her mother-in-law was still alive.

Only after her death in 1916 that Elisabeth officially became The Dowager Grand Duchess of Mecklenburg-Strelitz.

After the death of her eldest son, Grand Duke Adolf Frederick, in 1918 she inherited the 'hunting castle' of Prilvitz.

After her death, the castle of Prilvitz was inherited by her surviving children, which were her two adult daughters.